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Bupropion acts as an norepinephrine-dopamine reuptake inhibitor (NDRI).
Bupropion is helpful for smoking cessation in smokers with no history of depression; thus, the effectiveness of bupropion is not due to its antidepressant effect.
It was first approved for medical use in the United States in 1989.
It was originally called by the generic name amfebutamone, before being renamed in 2000.
It is an atypical antidepressant, different from most commonly prescribed antidepressants such as selective serotonin reuptake inhibitors (SSRIs).
Bupropion was first made by Nariman Mehta and patented by Burroughs Wellcome in 1969, which later became part of what is now Glaxo Smith Kline.